This module describes the common, currently understood epigenetic mechanisms of mammalian cells that contribute to carcinogenesis. It will explain an overall mechanism for each type of epigenetic modification and give specifics in veterinary oncology where they have been published. The student should be able to describe the effects of these epigenetic modifications on gene expression and cell function after this lecture.   

Learning Objectives

• How DNA methylation contributes to cancer
• How histone changes contribute to cancer 
• How miRNAs and IncRNAs contribute to cancer 
• The clinical impact of epigenetic changes