The objective of this module is to provide an overview of signal transduction in both normal and neoplastic cells, how dysregulated signaling contributes to tumor growth and methods used to target aberrant signaling in cancer cells. This module covers the following subjects:    

Learning Objectives

• Normal signal transduction and cellular homeostasis
• Major signal transduction pathways in cells (PI3 kinase, MAP Kinase, etc.)
• Causes of dysregulated signaling in cancer cells (e.g., mutations, etc.)
• Role of dysregulated signaling in supporting cancer cell growth/survival
• Methods and mechanisms to aberrant signal transduction in cancer (e.g., small molecular inhibitors)
• Resistance to small molecule inhibitors
• Application of small molecule inhibitors to veterinary cancers